The Peripheral Nerve Injury (PNI) Unit RNOH has a long-standing history of excellence in the treatment and management of adult and paediatric peripheral nerve injuries. Established to serve as a national centre for the care of complex nerve injuries, the Unit has grown to become a world-renowned facility for clinical innovation, research, and patient care in the field of peripheral nerve surgery including the following:
- Brachial/lumbosacral plexus surgery including obstetric (birth) injuries,
- Neurogenic thoracic outlet decompression (+/- excision of cervical or first rib),
- Brachial plexus/peripheral nerve open biopsy,
- Nerve sheath tumour excision biopsy
- Nerve exploration, decompression and neurolysis
- Nerve repair (neurorrhaphy),
- Nerve grafting,
- Neurectomy,
- Nerve transfer,
- Paediatric anterior shoulder release,
- Paediatric botulinum toxin injections,
- Paediatric shoulder reconstruction for instability/dislocation (glenoplasty),
- Paediatric derotation osteotomies of the upper limb
- Secondary reconstruction with tendon transfer
- Amputation for plexus injuries
- Revision and staged surgery
The roots of the PNI Unit trace back to Professor Herbert Seddon, who established the Peripheral Nerve Injury surgery at Oxford. Seddon’s work on nerve injuries laid the foundation for modern peripheral nerve surgery. Collaborating with biologists J.Z. Young and Peter Medawar, Seddon developed and advanced techniques for nerve repair, including his internationally adopted classification of nerve injuries into neurapraxia, axonotmesis, and neurotmesis. His publications in the 1940s became essential texts, and his 1954 monograph for the Medical Research Council was widely used to educate medical students on nerve injury principles.
In 1948, Seddon became Director of Postgraduate Studies at the Institute of Orthopaedics at the University of London and Clinical Director of the Royal National Orthopaedic Hospital. In 1965, he was appointed the first Professor of Orthopaedics at the University of London. His leadership in orthopaedic research and education, particularly his innovative postgraduate teaching programmes, earned national and international recognition.
During the 1980s and early 1990s, Professor Rolfe Birch and Mr. George Bonney collaborated to further to refine the understanding of nerve injuries, creating a dedicated Peripheral Nerve Injury Unit, originally at St. Mary’s Hospital, Paddington. They developed a simplified classification of nerve injuries as either conduction block/non-degenerative or degenerative lesions, building upon the work of Seddon and Sunderland. This refinement helped streamline the classification process, improving clinical diagnosis and management.
Upon Mr. Bonney’s retirement in 1991, Professor Birch moved the clinical unit to the Royal National Orthopaedic Hospital in Stanmore. This move further strengthened the unit’s collaborations with specialists at Queen’s Square, National Hospital for Neurology and Neurosurgery, and The Hammersmith Hospital. Professor Birch fostered a collaborative environment, facilitating transparency, open communication, and advancements in the field of nerve injury treatment.
In 2003, Professor Birch was appointed Consultant-in-Charge at the War Nerve Injuries Clinic at the Defence Medical Services Rehabilitation Unit, Headley Court, and he became Professor of Peripheral Neurological Surgery at University College London. Even after retiring from the NHS, his dedication to the field remained strong, as he continued running the clinic and contributing to the research of the department he founded.
Another key figure in the unit’s history is Professor Thomas Carlstedt, whose research into the reimplantation of avulsed spinal nerve roots into the spinal cord marked a major breakthrough in treating high brachial plexus injuries. His work continues to shape the management of severe nerve injuries and brachial plexus reimplantation.
Today, the PNI Unit is run by four full-time substantive Consultant Surgeons: Dr. Marco Sinisi, Mr. Mike Fox, Ms. Anna Panagiotidou, and Mr. Ashley Simpson. The Unit remains a hub of multidisciplinary collaboration, bringing together specialists in Orthopaedic surgery, Neurosurgery, Neurology, Radiology, and Rehabilitation medicine with frequent support from Vascular Surgery. Pioneering research, published in peer-reviewed PubMed-indexed journals and international conference presentations, has led to advances in nerve repair, including nerve grafting, transfers, and advanced diagnostics including electromyography (EMG) and MRI neurography. The publication of the surgical technique of glenoplasty in complex paediatric shoulder dislocation in 2011 was the first of its kind. The Unit is also exploring the application of artificial intelligence in diagnosing and predicting outcomes in peripheral nerve injuries.
As part of the RNOH’s commitment to innovation and education, the PNI Unit continues to train the next generation of surgeons and healthcare professionals offering both a national and international fellowship, thus maintaining its dedication to providing world-class care for even the most complex nerve injuries.