The RNOH will remain the UK’s leading specialist orthopaedic hospital, further enhancing its international profile for outstanding patient care, research and education

Cartilage Transplantation Stem Cell Project (SSCP)

Since its establishment and successful launch in 1998 by Professor George Bentley and his team, the RNOH has established itself as one of the leading centres in the world for repair of damaged knee joints by cartilage cell transplantation (Refs 1 and 2).

In that time, over 1500 patients have been treated with a high success rate of 70 to 80% resulting in relief of pain and a restoration of function as well as delaying the onset of severe osteoarthritis, which would require knee replacement surgery.

Furthermore, the unit has produced important data on cell-engineering of cartilage by the publication of 30+ papers in the scientific literature in the overall quest to prevent - as well as treat - osteoarthritis of the knee, which affects 25% of people over the age of 50.

The surgical procedure was performed in two stages (Ref. 3); the first being arthroscopy (telescopic examination of the knee) to take a small piece of normal cartilage which is sent to the cell culture laboratory. This cartilage is cultured for four to six weeks so that the cells are increased 30 times in number. These cells are then transplanted back into the damaged area of the knee by arthrotomy to grow and develop a new cartilage surface.

Stanmore Stem Cell Project (SSCP) ProcedureClick for full size image

The method has proved very valuable in relieving pain and restoring activity in younger patients, as shown in a study of the first 800 patients (Refs. 4 and 5). However, it requires two operations as well as the rehabilitation period before full activity is restored, taking some 12 months.

Recently, other techniques involving the patients’ own stem cells have been shown by Italian research teams to produce similar results. The advantage of their method is that it requires only one operation and the rehabilitation period may be shorter than 12 months (Ref 6).

This technique, which is now being employed with modifications at the RNOH, is performed in one stage only by a technique in which the cells for transplantation are taken from the patient’s own bone marrow in the pelvis. These cells are centrifuged to select the precursors of the stem cells which, when transplanted back into the damaged knee joint, will give rise to new cartilage cells and repair the defect.

This pilot study has commenced at the RNOH in younger patients (age 15 - 50 years-old) with painful knees and cartilage damage. It also promises potentially great possibilities for the treatment of other joints such as the hip, ankle and the upper limb joints.

Our experience, together with reports from the literature, have suggested that the rehabilitation period back to full activity could be shorter than 12 months and therefore a more rapid rehabilitation programme is being followed which is controlled by MRI (Magnetic Resonance Imaging) of the knee. This may show that the knee is healed sufficiently after only six months.

Patients treated by this method will be involved in a prospective clinical trial with full precautions and following strict ethical guidelines.

The RNOH staff involved in this study are:

Prof. George Bentley – lead investigator
Mr Richard Carrington – clinical lead
Prof.John Skinner - Professor of Orthopaedics(RNOH Director of Research)
Prof. Timothy Briggs - Professor of Orthopaedics
Mr James Donaldson - Consultant Orthopaedic Surgeon
Mr Jonathan Miles - Consultant Orthopaedic Surgeon
Dr Rikin Hargunani - Consultant Radiologist
Dr Umber Cheema - Senior Lecturer in Cell Biology.
Prof Alister Hart – Professor of Orthopaedics, University College London

The study is coordinated by the RNOH director of research studies, Ms Iva Haptmannova.

For further information contact: (020) 8909 5532.

References

  1. Homotransplantation of isolated epiphyseal and articular chondrocytes into joint surfaces. Bentley, G., Greer, R.B. Nature, Vol 230: 5293, 385 (1971).
  2. A prospective randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. Bentley, G., Biant, L.C., Carrington, R.W.J., Akmal, M., Goldberg, A., Williams, A., Skinner, J.A., Pringle, J.J.Bone and Joint Surg.Vol 85B;2003,223-230.
  3. Two to nine year outcome after autologous chondrocyte transplantation of the knee.
    Petersen, L., Minas, T., Brittberg, M., Nilsson, A., Sjogren-Jansson, E., Lindahl, A. Clin. Orthop. 374: 212-234, (2000).
  4. Minimum ten-year results of a prospective randomized study of autologous chondrocyteimplantation versus mosaicplasty for symptomatic articular cartilage defects of the knee.
    Bentley G, Biant L, Vijayan S, Macmull S, Skinner JA, Carrington R.
    Journal of Bone and Joint Surgery(Br), April 2012;94B.p504-509.
  5. Autologous chondrocyte implantation in the knee: mid-term to long-term results.
    Nawaz SZ, Bentley G, Gallagher K, Briggs TW, Skinner J, Carrington R.
    Journal of bone and joint surgery(Am), May 21,96(1),824-830.
  6. Osteochondral Lesions of the knee: a new one-step repair technique with bone marrow-derived cells.
    Buda R, Vannini F, Cavallo M, Grigolo B, Cennachi A, Giannini SJ.
    Journal of Bone and Joint Surgery(Am),2010;92, Suppl 2,11.

Professor George Bentley – August 2016

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Joint reconstruction: Cartilage transplantation